Verucerfont
Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.
Product Specifications
CAS Number
[885220-61-1]
Product Name Alternative
GSK561679
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Verucerfont.html
Purity
99.93
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
CC[C@H](NC1=CC(C)=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN12)C4=NC(C)=NO4
Molecular Formula
C22H26N6O2
Molecular Weight
406.48
Precautions
H302, H312, H315, H319
References & Citations
[1]Schwandt ML, et al. The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects. Neuropsychopharmacology. 2016 Nov;41 (12) :2818-2829.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CRFR1
Available Sizes
Curated Selection
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