BRD5648
BRD0705 is a paracrine-selective, orally bioavailable GSK3α inhibitor with a Kd of 4.8 μM and an IC50 of 66 nM, exhibiting 8-fold selectivity over GSK3β. It serves as a research tool for studying acute myeloid leukemia, with applications in both in vitro and in vivo experimental models. BRD5648 functions as its corresponding negative control compound.
Product Specifications
CAS Number
2056261-42-6
Product Name Alternative
Compound, BRD0705, BRD-0705, BRD 5648, BRD 0705, BRD5648, BRD-5648, control, (R) -enantiomer, (R) -BRD0705, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK3, GSK-3, GSK-3α, inhibit, negative
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
99.37% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.56 mM) ; DMSO:300 mg/mL (933.36 mM)
Smiles
CC[C@]1 (C2=CNNC2=NC2=C1C (=O) CC (C) (C) C2) c1ccccc1
Molecular Formula
C20H23N3O
Molecular Weight
321.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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