MYC degrader 1
MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors[1].
Product Specifications
CAS Number
2946670-96-6
UNSPSC
12352005
Target
C-Myc; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a80-2hcl.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC(C2=CC(C(F)(F)F)=C(N3CCC(CNCC4=CC(CN(C5C(NC(CC5)=O)=O)C6=O)=C6C=C4)CC3)N=C2)=CC=C1
Molecular Formula
C32H31ClF3N5O3
Molecular Weight
626.07
References & Citations
[1]Ma J, et al. MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nat Commun. 2024 Feb 29;15 (1) :1871.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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