G150
G150 is a potent and selective inhibitor of human cGAS (h-cGAS), effectively suppressing dsDNA-induced interferon expression with an IC50 of 10.2 nM. This small molecule is a valuable research tool for studying the cGAS-STING pathway in autoimmune, inflammatory, and cancer research contexts, applicable in both cellular and animal models.
Product Specifications
CAS Number
2369751-30-2
Product Name Alternative
THP1, high-throughput screening, Inhibitor, h-cGAS, G150, G-150, G 150, human myeloid cell, macrophage, inhibit, anti-inflammatory, cGAS, Cyclic GMP-AMP Synthase, dsDNA, dsDNA/cGAS
Field of Research
Immunology & Inflammation, Molecular Biology
Purity
97.39% (May vary between batches)
Solubility
DMSO:83.33 mg/mL (212.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.22 mM)
Smiles
Nc1ccc (cn1) -c1cc (Cl) c (Cl) c2[nH]c3CCN (Cc3c12) C (=O) CO
Molecular Formula
C18H16Cl2N4O2
Molecular Weight
391.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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