Lerociclib dihydrochloride
Lerociclib dihydrochloride (G1T38) is a highly potent and selective CDK4/6 inhibitor, demonstrating IC50 values of 1 nM and 2 nM against CDK4/CyclinD1 and CDK6/CyclinD3, respectively. It is a valuable research tool for investigating cell cycle progression and has shown antitumor activity in preclinical models of breast cancer and other malignancies.
Product Specifications
CAS Number
2097938-59-3
Product Name Alternative
Cyclin dependent kinase, CDK, CDK2/cyclinE, cdk2/cyclin A, CDK2/CyclinA, CDK1/cyclinB1, Cdk5/p25, CDK4/CyclinD1, Cdk4/cyclin D1, cdk6/cyclin D3, CDK6/CyclinD3, CDK5/p35, CDK7/Cyclin H/MAT1, CDK9/Cyclin T, CDK9/CyclinT, inhibit, Inhibitor, Lerociclib, Lerociclib Dihydrochloride, Lerociclib dihydrochloride, G1T38, G1T38 Dihydrochloride, G1T38 dihydrochloride
Field of Research
Cell Biology
Purity
97.40% (May vary between batches)
Solubility
H2O:95 mg/mL (173.51 mM) ; DMSO:1 mg/mL (1.83 mM) ; Saline:50 mg/mL (91.32 mM)
Smiles
Cl.Cl.CC (C) N1CCN (CC1) c1ccc (Nc2ncc3cc4C (=O) NCC5 (CCCCC5) n4c3n2) nc1
Molecular Formula
C26H36Cl2N8O
Molecular Weight
547.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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