HKI-357
HKI-357 is an irreversible dual inhibitor targeting EGFR and ERBB2 with IC50 values of 34 nM and 33 nM, respectively. It effectively blocks EGFR autophosphorylation at Y1068 and downstream AKT and MAPK signaling. This compound is a valuable research tool for investigating oncogenic receptor tyrosine kinase pathways in both in vitro and in vivo cancer models.
Product Specifications
CAS Number
848133-17-5
Product Name Alternative
ErbB-1, ERBB2, ErbB2, Epidermal growth factor receptor, EGFR, HER1, HKI 357, HKI357, HKI-357, inhibit, Inhibitor, NSCLCs
Field of Research
Cardiovascular Research, Signal Transduction
Purity
95.11% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.48 mM) ; DMSO:30 mg/mL (52.26 mM)
Smiles
CCOc1cc2ncc (C#N) c (Nc3ccc (OCc4cccc (F) c4) c (Cl) c3) c2cc1NC (=O) \C=C\CN (C) C
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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