Leflunomide
Leflunomide (HWA486) is a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid and psoriatic arthritis. Its active metabolite, teriflunomide, inhibits dihydroorotate dehydrogenase (DHODH), suppressing pyrimidine synthesis in proliferating lymphocytes. This mechanism is validated in both in vitro cellular assays and in vivo animal models of autoimmune disease.
Product Specifications
CAS Number
75706-12-6
Product Name Alternative
RS-34821
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
DHODH inhibitor; immunosuppresant
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml) .
Smiles
CC1=C (C=NO1) C (=O) NC1=CC=C (C=C1) C (F) (F) F
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Storage Conditions
RT
Notes
For research use only.
Other Product Names
5-Methyl-N-[4- (trifluoromethyl) phenyl]-4-isoxazolecarboxamide
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