IRAK4-IN-4
IRAK4-IN-4 is a potent dual-target inhibitor, demonstrating high activity against both cyclic GMP-AMP synthase (cGAS; IC50 = 2.1 nM) and interleukin-1 receptor-associated kinase 4 (IRAK4; IC50 = 2.8 nM) . This compound is a valuable research tool for investigating innate immune signaling pathways, including the cGAS-STING and TLR/IL-1R axes, in both cellular and biochemical studies.
Product Specifications
CAS Number
1850276-58-2
Product Name Alternative
Inhibitor, Interleukin-1 receptor associated kinase, IL-1R associated kinase, IRAK, IRAK4IN4, IRAK-4-IN-4, IRAK4-IN-4, IRAK4, IRAK4 IN 4, inhibit, cGAS, Cyclic GMP-AMP synthase, Cyclic GMP-AMP Synthase
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
99.13% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.88 mM) ; DMSO:24 mg/mL (70.51 mM)
Smiles
Cc1ccn2c (C (=O) C (=O) c3ccccc3) c (nc2c1) -c1ccccc1
Molecular Formula
C22H16N2O2
Molecular Weight
340.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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