Eltanexor
Eltanexor (ONO-7706) is an orally bioavailable, potent inhibitor of exportin-1 (XPO1) with an EC50 of 60.9 nM. It induces caspase-dependent apoptosis in leukemic cell lines and has demonstrated anti-leukemic activity in preclinical in vitro and in vivo research models.
Product Specifications
CAS Number
1642300-52-4
Product Name Alternative
ATG 016, ATG016, ATG-016, Eltanexor, KPT8602, KPT-8602, KPT 8602, ONO7706, ONO-7706, ONO 7706, XPO1
Field of Research
Pharmacology & Drug Discovery
Purity
≥98% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.71 mM) ; DMSO:80 mg/mL (186.79 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
NC (=O) C (=C 1cnc (n1) -c1cc (cc (c1) C (F) (F) F) C (F) (F) F) \c1cncnc1
Molecular Formula
C17H10F6N6O
Molecular Weight
428.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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