LCH-7749944
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor (IC50 = 14.93 μM) that suppresses human gastric cancer cell proliferation by targeting the PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. This small molecule is a useful research tool for studying oncogenic signaling and cell cycle mechanisms in vitro.
Product Specifications
CAS Number
796888-12-5
Product Name Alternative
Apoptosis, apoptosis, cancer, c-Src, cyclin, cells, EGFR, human, GNF-PF 2356, GNF-PF2356, GNF-PF-2356, Inhibitor, gastric, LCH 7749944, LCH7749944, LCH-7749944, inhibit, PAK4, PAK, p21 activated kinases, proliferation
Field of Research
Cell Biology, Signal Transduction
Purity
99.28% (May vary between batches)
Solubility
DMSO:250 mg/mL (713.45 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.27 mM)
Smiles
COc1cccc (Nc2nc (NCC3CCCO3) c3ccccc3n2) c1
Molecular Formula
C20H22N4O2
Molecular Weight
350.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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