LEQ506
LEQ506 is a potent and selective small molecule inhibitor of Smoothened (Smo), demonstrating IC50 values of 2 nM for human and 4 nM for mouse Smo. It is a valuable research tool for investigating Hedgehog signaling pathway biology in both in vitro cellular assays and in vivo preclinical models.
Product Specifications
CAS Number
1204975-42-7
Product Name Alternative
Inhibit, Inhibitor, mSmo, mouse smo, NVP-LEQ 506, NVP-LEQ506, NVP-LEQ-506, hSmo, human smo, LEQ506, LEQ-506, LEQ 506, Smo, Smoothened
Field of Research
Stem Cell & Developmental Biology
Purity
98.53% (May vary between batches)
Solubility
DMSO:100 mg/mL (231.18 mM)
Smiles
C[C@@H]1CN (CCN1c1cnc (cn1) C (C) (C) O) c1nnc (Cc2ccccc2) c (C) c1C
Molecular Formula
C25H32N6O
Molecular Weight
432.56
Storage Conditions
-20°C
Notes
For research use only.
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