Irinotecan HCl
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) is a topoisomerase I inhibitor that stabilizes the DNA-enzyme complex, preventing DNA religation and causing lethal double-strand breaks. It is widely used in cancer research for studying chemotherapy mechanisms and efficacy in both cellular and animal models.
Product Specifications
CAS Number
136572-09-3
Product Name Alternative
Topo I, Topoisomerase, Autophagy, (+) -Irinotecan hydrochloride, CPT-11 hydrochloride, CPT-11 HCl, CPT-11 HCl Trihydrate, inhibit, Irinotecan HCl, Irinotecan HCl Trihydrate, Irinotecan hydrochloride, Irinotecan Hydrochloride, Irinotecan hydrochloride trihydrate, Irinotecan hydrochloride Trihydrate, Inhibitor
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Topoisomerase I inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml) .
Smiles
O.O.O.Cl.CCc1c2Cn3c (cc4c (COC (=O) [C@]4 (O) CC) c3=O) -c2nc2ccc (OC (=O) N3CCC (CC3) N3CCCCC3) cc12
Molecular Formula
C33H38N4O6 ∙ HCl ∙ 3H20
Molecular Weight
586.69 ∙ 36.46 ∙ 54.05
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(S) -4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride
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