Irinotecan Hydrochloride
Irinotecan Hydrochloride (CPT-11 hydrochloride) is a prodrug converted to the potent topoisomerase I inhibitor SN-38, causing S-phase-specific DNA damage and apoptosis. It is widely used in cancer research for in vitro cytotoxicity assays and in vivo xenograft studies, particularly for colorectal and pancreatic cancer models.
Product Specifications
CAS Number
100286-90-6
Product Name Alternative
CPT11 Hydrochloride, CPT-11 Hydrochloride, CPT-11 hydrochloride, CPT11, CPT-11, CPT 11, CPT 11 Hydrochloride, (+) -Irinotecan, Camptothecin 11 Hydrochloride, Camptothecin 11 hydrochloride, Autophagy, Inhibitor, inhibit, Irinotecan, Irinotecan Hydrochloride, Topoisomerase, Topo I
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:65 mg/mL (104.31 mM) ; H2O:3.12 mg/mL (5.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.02 mM)
Smiles
Cl.CCc1c2Cn3c (cc4c (COC (=O) [C@]4 (O) CC) c3=O) -c2nc2ccc (OC (=O) N3CCC (CC3) N3CCCCC3) cc12
Molecular Formula
C33H39ClN4O6
Molecular Weight
623.14
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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