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Dooku1

Dooku1 is a Yoda1 analog and selective Piezo1 channel antagonist, inhibiting Yoda1-evoked Ca2+ influx with IC50 values of ~1.3-1.5 μM in HEK 293 cells and HUVECs. It also blocks Yoda1-induced aortic relaxation, making it a useful research tool for studying Piezo1 mechanobiology in cardiovascular and cellular physiology.

Product Specifications

CAS Number

2253744-54-4

Product Name Alternative

Dooku 1, Dooku1, Dooku-1, Inhibitor, nAChR, inhibit, Piezo Channel, PiezoChannel

Field of Research

Pharmacology & Drug Discovery

Purity

98.87% (May vary between batches)

Solubility

10% DMSO+90% Corn Oil:3.3 mg/mL (10.12 mM) ; DMSO:120 mg/mL (367.87 mM)

Smiles

Clc1cccc (Cl) c1CSc1nnc (o1) -c1ccc[nH]1

Molecular Formula

C13H9Cl2N3OS

Molecular Weight

326.2

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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