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EN6

EN6 is a small-molecule, in vivo autophagy activator that covalently modifies the v-ATPase subunit ATP6V1A at Cys-277. This modification inhibits mTORC1 signaling, enhances lysosomal acidification, and promotes the clearance of protein aggregates like TDP-43, relevant to frontotemporal dementia research.

Product Specifications

CAS Number

1808714-73-9

Product Name Alternative

Autophagy, inhibit, Inhibitor, EN 6, EN6, EN-6, Proton Pump, Proton pump, Protonpump

Field of Research

Cell Biology, Pharmacology & Drug Discovery

Purity

95.16% (May vary between batches)

Solubility

DMSO:5.43 mg/mL (14.74 mM) ; Ethanol:1.1 mg/mL (2.99 mM)

Smiles

Fc1ccc (NC (=O) c2cnn (c2) -c2ccccc2F) cc1NC (=O) C=C

Molecular Formula

C19H14F2N4O2

Molecular Weight

368.34

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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