EN6
EN6 is a small-molecule, in vivo autophagy activator that covalently modifies the v-ATPase subunit ATP6V1A at Cys-277. This modification inhibits mTORC1 signaling, enhances lysosomal acidification, and promotes the clearance of protein aggregates like TDP-43, relevant to frontotemporal dementia research.
Product Specifications
CAS Number
1808714-73-9
Product Name Alternative
Autophagy, inhibit, Inhibitor, EN 6, EN6, EN-6, Proton Pump, Proton pump, Protonpump
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
95.16% (May vary between batches)
Solubility
DMSO:5.43 mg/mL (14.74 mM) ; Ethanol:1.1 mg/mL (2.99 mM)
Smiles
Fc1ccc (NC (=O) c2cnn (c2) -c2ccccc2F) cc1NC (=O) C=C
Molecular Formula
C19H14F2N4O2
Molecular Weight
368.34
Storage Conditions
-20°C
Notes
For research use only.
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