ESI-08
ESI-08 is a selective EPAC2 antagonist with an IC50 of 8.4 μM, effectively inhibiting cAMP-induced EPAC activation without affecting PKA. This tool compound is widely used in vitro and in vivo to study EPAC2's role in insulin secretion, neuronal signaling, and cardiovascular function.
Product Specifications
CAS Number
301177-43-5
Product Name Alternative
CAMP, inhibit, Inhibitor, EPAC1, EPAC, EPAC2, exchange, ESI 08, ESI08, ESI-08, Ras, proteins
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
97.17% (May vary between batches)
Solubility
DMSO:50 mg/mL (141.45 mM)
Smiles
Cc1ccc (C) c (CSc2nc (C3CCCCC3) c (C#N) c (=O) [nH]2) c1
Molecular Formula
C20H23N3OS
Molecular Weight
353.48
Storage Conditions
-20°C
Notes
For research use only.
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