F-1
F-1 is a potent dual ALK/ROS1 inhibitor with IC50 values of 2.1 nM (ALKWT), 2.3 nM (ROS1WT), 1.3 nM (ALKL1196M), and 3.9 nM (ALKG1202R) . It effectively suppresses phospho-ALK and downstream signaling, making it a valuable tool compound for in vitro and in vivo cancer research targeting ALK and ROS1-driven malignancies.
Product Specifications
CAS Number
2244775-31-1
Product Name Alternative
Inhibit, Inhibitor, F 1, F-1, F1, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, ALK, ALK tyrosine kinase receptor, Cluster of differentiation 246, CD246, ROS1, ROSKinase, ROS Kinase
Field of Research
Cardiovascular Research, Immunology & Inflammation, Signal Transduction
Purity
97.66% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.71 mM) ; DMSO:100 mg/mL (192.67 mM)
Smiles
COc1nc (ccc1Nc1ncc (Cl) c (Nc2ccccc2NS (C) (=O) =O) n1) N1CCN (C) CC1
Molecular Formula
C22H27ClN8O3S
Molecular Weight
519.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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