FG 7142
FG 7142 is a benzodiazepine inverse agonist with high affinity for α1 subunit-containing GABAA receptors (Ki=91 nM) . It modulates GABA-induced chloride flux and has been used in research to study anxiety-related neurochemistry, including in vivo effects on cortical tyrosine hydroxylation and β-adrenoceptor upregulation in mice.
Product Specifications
CAS Number
78538-74-6
Product Name Alternative
Dopaminergic, FG 7142, FG7142, FG-7142, GABAReceptor, GABA Receptor, GABAA, GABAA receptor, Gamma-aminobutyric acid Receptor, Inhibitor, inhibit, inverse agonist, nucleus accumben, LSU 65, LSU65, LSU-65, ZK39106, ZK-39106, ZK 39106, tyrosine hydroxylase, γ-Aminobutyric acid Receptor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.75% (May vary between batches)
Solubility
DMSO:30 mg/mL (133.19 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.88 mM)
Smiles
CNC (=O) c1cc2c (cn1) [nH]c1ccccc21
Molecular Formula
C13H11N3O
Molecular Weight
225.25
Storage Conditions
-20°C
Notes
For research use only.
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