FGFR1/DDR2 inhibitor 1
This small molecule is a potent dual inhibitor of DDR2 and FGFR1, exhibiting IC50 values of 3.2 nM and 31.1 nM, respectively. It is a valuable research tool for studying kinase signaling in cancer models, including leukemia cell lines like KG-1, in both in vitro and in vivo experimental settings.
Product Specifications
CAS Number
2308497-58-5
Product Name Alternative
Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor, DiscoidinDomainReceptor (DDR), cells, DDR, DDR2, Fibroblast growth factor receptor, FGFR, FGFR1, FGFR1/DDR2 inhibitor 1, FGFR-1/DDR2 inhibitor 1, NCI-H1581, NCI-H2286, Nude, mice, inhibit, Inhibitor, KG-1, phosphorylation, SCID, tumor
Field of Research
Cardiovascular Research, Musculoskeletal & Connective Tissue Research; Pharmacology & Drug Discovery, Signal Transduction
Purity
99.14% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (6.58 mM) ; DMSO:250 mg/mL (498.5 mM) ; H2O:< 0.1 mg/mL (insoluble)
Smiles
Cc1ccc (cc1-c1ccc2c (n[nH]c2c1) -c1cnn (c1) C1CC1) C (=O) Nc1cccc (c1) C (F) (F) F
Molecular Formula
C28H22F3N5O
Molecular Weight
501.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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