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LSP-249

LSP-249 is a potent small molecule inhibitor of plasma kallikrein, exhibiting an EC50 below 100 nM in cellular assays. It is a valuable research tool for investigating hereditary angioedema (HAE) pathophysiology and for preclinical in vitro and in vivo studies targeting kallikrein-mediated pathways.

Product Specifications

CAS Number

1801253-04-2

Product Name Alternative

Angioedema, LSP 249, LSP249, LSP-249, Inhibitor, kallikrein, kallikrein in cell, inhibit, Threonine proteases, Serine proteases, Ser/Thr Protease, Serine endopeptidases

Field of Research

Protein Biochemistry

Purity

99.27% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.63 mM) ; DMSO:31.25 mg/mL (72.35 mM)

Smiles

Cc1cc (N) nc (C) c1CNC (=O) c1ccnc (Cc2ccc3ncc (Cl) cc3c2) c1

Molecular Formula

C24H22ClN5O

Molecular Weight

431.92

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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