Niraparib (R-enantiomer)
MK 4827 R-enantiomer is the R-enantiomeric form of niraparib, functioning as a potent PARP1 inhibitor with an IC50 of 2.4 nM. This compound is utilized in cancer research, particularly for studying synthetic lethality in BRCA-deficient models, and has been investigated in both cellular assays and in vivo xenograft studies.
Product Specifications
CAS Number
1038915-58-0
Product Name Alternative
Inhibit, poly ADP ribose polymerase, Niraparib, Niraparib (R enantiomer), Niraparib (Renantiomer), Niraparib (R-enantiomer), Niraparib R-enantiomer, MK-4827, MK 4827, MK 4827 (R-enantiomer), MK4827, PARP, PARP1, Inhibitor
Field of Research
Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
99.41% (May vary between batches)
Solubility
DMSO:30 mg/mL (93.64 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.24 mM)
Smiles
NC (=O) c1cccc2cn (nc12) -c1ccc (cc1) [C@H]1CCCNC1
Molecular Formula
C19H20N4O
Molecular Weight
320.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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