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Mutant IDH1-IN-2

Mutant IDH1-IN-2 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1, exhibiting IC50 values below 22 nM in biochemical assays. This small molecule is a valuable research tool for investigating oncogenic IDH1 function in cancers like glioma and AML, supporting both in vitro and in vivo mechanistic studies.

Product Specifications

CAS Number

1429176-69-1

Product Name Alternative

IsocitrateDehydrogenase (IDH), IsocitrateDehydrogenase, Isocitrate Dehydrogenase (IDH), Isocitrate Dehydrogenase, Mutant IDH1IN2, Mutant IDH-1-IN-2, Mutant IDH1-IN-2, Mutant IDH1 IN 2, inhibit, Inhibitor, IDH

Field of Research

Metabolism Research

Purity

99.11% (May vary between batches)

Solubility

DMSO:9 mg/mL (19.59 mM) ;10% DMSO+90% Corn Oil:0.5 mg/mL (1.09 mM) ; H2O:< 0.1 mg/mL (insoluble)

Smiles

CC (C) [C@H]1COC (=O) N1c1ccnc (N[C@@H] (C) c2ccc (CN3CCC (F) (F) CC3) cc2) n1

Molecular Formula

C24H31F2N5O2

Molecular Weight

459.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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