NB-360
NB-360 is a potent, brain-penetrant small molecule inhibitor of BACE1 and BACE2, demonstrating low nanomolar IC50 values against both human and mouse enzymes with high selectivity over related aspartyl proteases. It is a valuable research tool for investigating BACE function in Alzheimer's disease models, supporting both in vitro biochemical assays and in vivo pharmacological studies.
Product Specifications
CAS Number
1262857-73-7
Product Name Alternative
β-Secretase, Inhibitor, inhibit, Mouse , human BACE1, NB 360, NB360, NB-360, Beta-secretase, BACE1, BACE2, BACE
Field of Research
Neuroscience
Purity
99.25% (May vary between batches)
Solubility
DMSO:45 mg/mL (100.13 mM)
Smiles
Cc1cc (cnc1C (=O) Nc1ccc (F) c (c1) [C@]1 (C) CO[C@] (C) (C (N) =N1) C (F) (F) F) C#N
Molecular Formula
C21H19F4N5O2
Molecular Weight
449.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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