NCGC00229600
NCGC00229600 is a small molecule allosteric inverse agonist of the thyrotropin receptor (TSHR) . It effectively blocks receptor activation induced by both TSH and stimulating autoantibodies, making it a valuable research tool for investigating Graves' disease pathogenesis and potential therapeutics in both cellular and animal models.
Product Specifications
CAS Number
1338824-20-6
Product Name Alternative
Graves, fibroblasts, endogenously, Inhibitor, inhibit, NCGC 00229600, NCGC00229600, NCGC-00229600, disease, antibody, cAMP, Thyroid-stimulating hormone Receptor, Thyrotropin receptor, thyrotropin receptor (TSHR), TSHReceptor, TSH Receptor
Field of Research
Pharmacology & Drug Discovery
Purity
99.27% (May vary between batches)
Solubility
DMSO:40 mg/mL (83.41 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (4.17 mM)
Smiles
COc1ccc (cc1COc1c (C) cccc1C) C1Nc2ccccc2C (=O) N1Cc1cccnc1
Molecular Formula
C30H29N3O3
Molecular Weight
479.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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