Olcegepant
Olcegepant (BIBN-4096) is a potent and highly selective small-molecule antagonist of the human CGRP1 receptor, exhibiting sub-nanomolar affinity (Ki = 14.4 pM) . It is widely used in migraine research to investigate CGRP receptor function in both in vitro binding assays and in vivo animal models of neurogenic inflammation and vasodilation.
Product Specifications
CAS Number
204697-65-4
Product Name Alternative
BIBN 4096, BIBN 4096BS, BIBN4096, BIBN-4096, Calcitonin gene-related peptide receptor, CGRP1, CGRPReceptor, CGRP Receptor, Olcegepant, inhibit, Inhibitor, hCGRP
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
96.08% (May vary between batches)
Solubility
DMSO:23.81 mg/mL (27.38 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.3 mM)
Smiles
O=C1N (CC=2C (N1) =CC=CC2) C3CCN (C (N[C@H] (CC4=CC (Br) =C (O) C (Br) =C4) C (N[C@H] (C (=O) N5CCN (CC5) C=6C=CN=CC6) CCCCN) =O) =O) CC3
Molecular Formula
C38H47Br2N9O5
Molecular Weight
869.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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