Etoposide (VP-16)
Etoposide (VP-16-213) is a chemotherapeutic topoisomerase II inhibitor that stabilizes the enzyme-DNA complex, blocking DNA replication (IC50=60.3 μM) . It is widely used in cancer research to study mechanisms of apoptosis and autophagy in both cellular and animal models of various malignancies.
Product Specifications
CAS Number
33419-42-0
Product Name Alternative
NSC 141540
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Topoisomerase II inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) .
Smiles
O=C1[C@@]2 ([C@@H] (C=3C ([C@@H] (O[C@@H]4O[C@]5 ([C@] ([C@H] (O) [C@H]4O) (O[C@H] (C) OC5) [H]) [H]) [C@]2 (CO1) [H]) =CC6=C (C3) OCO6) C7=CC (OC) =C (O) C (OC) =C7) [H]
Molecular Formula
C29H32O13
Molecular Weight
588.6
Storage Conditions
RT
Notes
For research use only.
Other Product Names
4′-Demethylepipodophyllotoxin 9- (4,6-O-ethylidene-β-D-glucopyranoside
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