Bosutinib
Bosutinib (SKI-606) is a dual Abl and Src kinase inhibitor with IC50 values of 1 nM and 1.2 nM, respectively. This synthetic quinolone derivative is widely used in preclinical research for investigating chronic myeloid leukemia (CML) and solid tumors, demonstrating activity in both cellular assays and animal models.
Product Specifications
CAS Number
380843-75-4
Product Name Alternative
SKI-606
Field of Research
Cell Biology, Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Src/Abl kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml with warming) .
Smiles
N (C=1C2=C (C=C (OCCCN3CCN (C) CC3) C (OC) =C2) N=CC1C#N) C4=CC (OC) =C (Cl) C=C4Cl
Molecular Formula
C26H29Cl2N5O3
Molecular Weight
530.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[ (2,4-Dichloro-5-methoxyphenyl) amino]-6-methoxy-7-[3- (4-methyl-1-piperazinyl) propoxy]-3-quinolinecarbonitrile
Available Sizes
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