(-) -Coclaurine (hydrochloride)

(-) -Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-) -Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist[1].

Product Specifications

CAS Number

[3422-42-2]

Product Name Alternative

(-) - (S) -Coclaurine (hydrochloride) ; L-Coclaurine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-coclaurine-hydrochloride.html

Purity

98.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(O)C=C2C(CCN[C@H]2CC3=CC=C(O)C=C3)=C1.Cl

Molecular Formula

C17H20ClNO3

Molecular Weight

321.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Tomita M, et al. Studies on the Alkaloids of Menispermaceous Plants. XCII Alkaloids of Cocculus laurifolius DC. (Suppl. I.) Optical Rotation of Coclaurine[J]. Yakugaku Zasshi, 1952, 72 (2) : 280-281.