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NLRP3-IN-48

NLRP3-IN-48 is an NLRP3 inhibitor. NLRP3-IN-48 targets the NLRP3 protein, affecting the assembly of the NLRP3 inflammasome and thereby inhibiting its activation. NLRP3-IN-48 has anti-inflammatory activity in a mouse model of acute colitis induced by DSS[1].

Product Specifications

UNSPSC

12352211

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-48.html

Smiles

CC/C=C(C)/C(NC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2/C=C/[N+]([O-])=O)C=C1)=O

Molecular Formula

C24H26N2O5

Molecular Weight

422.47

References & Citations

[1]Ruan B, et al. Design, Synthesis, in Vitro and in Vivo Biological Evaluation of Pterostilbene Derivatives for the Treatment of Inflammatory Bowel Disease. Chem Biodivers. 2024 Aug 9:e202401081.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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