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PF-06424439 methanesulfonate

PF-06424439 methanesulfonate is a potent and selective DGAT2 inhibitor with an IC50 of 14 nM. This orally available, noncompetitive, and slowly reversible inhibitor is used in research to investigate lipid metabolism in both in vitro and in vivo models, particularly for metabolic and liver disease studies.

Product Specifications

CAS Number

1469284-79-4

Product Name Alternative

Mono- acylglycerol acyltransferase, Inhibitor, inhibit, Acyltransferase, acyl-CoA:cholesterol acyltransferase, DGAT2, Diacylglycerol acyltransferase, Diglyceride acyltransferase, PF 06424439, PF 06424439 methanesulfonate, PF06424439, PF-06424439, PF06424439 methanesulfonate, PF-06424439 methanesulfonate

Field of Research

Metabolism Research

Purity

99.77% (May vary between batches)

Solubility

H2O:99 mg/mL (184.68 mM) ; DMSO:262.5 mg/mL (489.69 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.33 mM)

Smiles

CS (O) (=O) =O.Clc1cnn (c1) C1 (CC1) c1nc2ccc (nc2[nH]1) N1CCC[C@H] (C1) C (=O) N1CCCC1

Molecular Formula

C23H30ClN7O4S

Molecular Weight

536.05

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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