PF-06726304
PF-06726304 is a potent and selective EZH2 inhibitor, effective against both wild-type and mutant Y641N forms with Kis of 0.7 nM and 3.0 nM, respectively. It demonstrates robust antitumor activity in preclinical research, making it a valuable tool for investigating epigenetics in oncology, both in vitro and in vivo.
Product Specifications
CAS Number
1616287-82-1
Product Name Alternative
Y641N, PF 06726304, PF06726304, PF-06726304, antitumor, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, EZH2, EZH2 WT, EZH2 Y641N, H3K27me3, inhibit, Karpas-422
Field of Research
Epigenetics & Chromatin
Purity
98.19% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.24 mM) ; DMSO:45 mg/mL (100.82 mM)
Smiles
Cc1noc (C) c1-c1cc (Cl) c2CCN (Cc3c (C) cc (C) [nH]c3=O) C (=O) c2c1Cl
Molecular Formula
C22H21Cl2N3O3
Molecular Weight
446.33
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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