PF-06928215
PF-06928215 is a potent small molecule inhibitor of the cGAS enzyme, demonstrating an IC50 of 4.9 μM. It is a valuable research tool for investigating the cGAS-STING signaling pathway in both cellular and animal models of autoimmunity, viral infection, and cancer.
Product Specifications
CAS Number
2378173-15-8
Product Name Alternative
Cyclic GMP-AMP Synthase, cGAS, inhibit, Inhibitor, PF 06928215, PF06928215, PF-06928215
Field of Research
Immunology & Inflammation
Purity
98.73% (May vary between batches)
Solubility
DMSO:33.33 mg/mL (87.62 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM)
Smiles
OC (=O) [C@@H]1CCCC[C@@H]1NC (=O) c1cnn2c (O) cc (nc12) -c1ccccc1
Molecular Formula
C20H20N4O4
Molecular Weight
380.4
Storage Conditions
-20°C
Notes
For research use only.
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