Pyrotinib dimaleate
Pyrotinib dimaleate is a potent and selective dual inhibitor of EGFR and HER2, with respective IC50 values of 13 nM and 38 nM. It is a key research compound for studying HER2-positive breast cancer, demonstrating efficacy in both cellular assays and animal models.
Product Specifications
CAS Number
1397922-61-0
Product Name Alternative
HER1, HER2, Inhibitor, Epidermal growth factor receptor, EGFR, ErbB-1, inhibit, Pyrotinib Dimaleate, Pyrotinib, Pyrotinib dimaleate, SHR 1258 Dimaleate, SHR 1258, SHR-1258, SHR1258 Dimaleate, SHR-1258 dimaleate, SHR-1258 Dimaleate, SHR1258
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.27% (May vary between batches)
Solubility
DMSO:240 mg/mL (294.4 mM) ; H2O:50 mg/mL (61.33 mM) ; Ethanol:40 mg/mL (49.07 mM)
Smiles
OC (=O) \C=C/C (O) =O.OC (=O) \C=C/C (O) =O.CCOc1cc2ncc (C#N) c (Nc3ccc (OCc4ccccn4) c (Cl) c3) c2cc1NC (=O) \C=C\[C@H]1CCCN1C
Molecular Formula
C40H39ClN6O11
Molecular Weight
815.22
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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