PT2399
PT2399 is a selective, orally bioavailable HIF-2α inhibitor that disrupts its dimerization with HIF-1β. It demonstrates significant antitumor efficacy in preclinical in vivo models, making it a valuable chemical probe for researching hypoxia signaling pathways in renal cell carcinoma and other cancers.
Product Specifications
CAS Number
1672662-14-4
Product Name Alternative
Inhibitor, inhibit, Hypoxia-inducible factors, HIFs, HIF-PH, HIFProlylHydroxylase, HIF-2α, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, PT2399, PT-2399, PT 2399
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research
Purity
98.80% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.92 mM) ; DMSO:262.5 mg/mL (626.01 mM)
Smiles
O[C@H]1c2c (CC1 (F) F) c (Oc1cc (F) cc (c1) C#N) ccc2S (=O) (=O) C (F) F
Molecular Formula
C17H10F5NO4S
Molecular Weight
419.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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