Talmapimod
Talmapimod (SCIO-469) is a potent, orally bioavailable, and highly selective ATP-competitive inhibitor of p38α MAP kinase (IC50 = 9 nM) . It demonstrates significant selectivity over p38β and other kinases. This compound has been utilized in research to investigate p38α's role in inflammatory pathways in both cellular and animal models.
Product Specifications
CAS Number
309913-83-5
Product Name Alternative
Cells, cytotoxicity, Hsp27, Inhibitor, inhibit, myeloma, multiple, p38 MAPK, p38α, p38β, p38MAPK, phosphorylation, Talmapimod, SCIO 469, SCIO469, SCIO-469, tumor
Field of Research
Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:95 mg/mL (185.19 mM)
Smiles
C[C@H]1CN ([C@H] (C) CN1Cc1ccc (F) cc1) C (=O) c1cc2c (cn (C) c2cc1Cl) C (=O) C (=O) N (C) C
Molecular Formula
C27H30ClFN4O3
Molecular Weight
513
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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