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Sigma-1 receptor antagonist 2

This small molecule is a potent and selective sigma-1 receptor (σ1R) antagonist, exhibiting a Ki of 3.88 nM for σ1R versus 1288 nM for σ2R. It is a valuable research tool for investigating σ1R function in neuropathic pain, neurodegenerative diseases, and psychiatric disorders in both in vitro and in vivo models.

Product Specifications

CAS Number

1639220-15-7

Product Name Alternative

Inhibit, Inhibitor, Sigmareceptor, Sigma1 receptor antagonist 2, Sigma-1 receptor antagonist 2, Sigma 1 receptor antagonist 2, Sigma receptor, Sigma Receptor, σ1 receptor, σ-1 receptor antagonist 2, σ1, σ2 receptor

Field of Research

Pharmacology & Drug Discovery

Purity

99.52% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.78 mM) ; DMSO:86.67 mg/mL (230.57 mM)

Smiles

COc1ccc (cc1) -c1nc (C) c (Cl) c (OCCCN2CCCCC2) n1

Molecular Formula

C20H26ClN3O2

Molecular Weight

375.89

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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