SM-164

SM-164 is a potent small molecule antagonist of XIAP, binding with high affinity (IC50: 1.39 nM) to its BIR2 and BIR3 domains. This compound is a valuable research tool for studying apoptosis regulation and has demonstrated pro-apoptotic activity in various cancer cell lines in vitro.

Product Specifications

CAS Number

957135-43-2

Product Name Alternative

Inhibit, IAP, Inhibitor, Apoptosis, cIAP2, cIAP-2, cIAP, cIAP1, cIAP-1, XIAP, SM164, SM-164, SM 164

Field of Research

Cell Biology

Purity

>98%

Bioactivity

Smac mimetic

Form

Powder

Solubility

Soluble in DMSO (50 mg/ml)

Smiles

[H][C@]12CC[C@H] (N1C (=O) [C@H] (CCCC2) NC (=O) [C@H] (C) NC) C (=O) N[C@H] (c1cn (CCCCc2ccc (CCCCn3cc (nn3) [C@@H] (NC (=O) [C@@H]3CC[C@]4 ([H]) CCCC[C@H] (NC (=O) [C@H] (C) NC) C (=O) N34) c3ccccc3) cc2) nn1) c1ccccc1

Molecular Formula

C62H84N14O6

Molecular Weight

1121.4

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

(3S,3′S,6S,6′S,10aS,10′aS) -N, N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[ (S) -phenylmethylene]]]bis[decahydro-6-[[ (2S) -2- (methylamino) -1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide