Serpin E1, Rat (HEK293, His)

Serpin E1 Protein, Rat (HEK293, His) is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. The Serpin E1 protein is a single-chain glycoprotein composed of 379 amino acids. The active site of the protein is Arg346-Met347. SERPINE1 encodes plasminogen activator inhibitor type 1 (PAI-1), which serves as the primary inhibitor of urokinase plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). The Serpin E1 protein can quickly inhibit the formation of plasmin. Serpin E1 can be transcribed through several signaling cascades, including pro-fibrogenic and pro-inflammatory pathways. Serpin E1 is a serine proteinase inhibitor, serves as an important regulator of extracellular matrix remodeling[1][2][3]. Serpin E1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of Serpin E1 Protein, Rat (HEK293, His) is 379 a.a., with molecular weight of 48-60 kDa.

SPLPESHTAQ QATNFGVKVF QHVVQASKDR NVVFSPYGVS SVLAMLQLTT AGKTRQQIQD AMGFNISERG TAPALRKLSK ELMGSWNKNE ISTADAIFVQ RDLELVQGFM PHFFKLFRTT VKQVDFSEVE RARFIINDWV ERHTKGMISD LLAKGAVNEL TRLVLVNALY FNGQWKTPFL EASTHQRLFH KSDGSTISVP MMAQNNKFNY TEFTTPDGHE YDILELPYHG ETLSMFIAAP FEKDVPLSAI TNILDAELIR QWKSNMTRLP RLLILPKFSL ETEVDLRGPL EKLGMTDIFS STQADFTSLS DQEQLSVAQA LQKVKIEVNE SGTVASSSTA ILVSARMAPT EMVLDRSFLF VVRHNPTETI LFMGQLMEP