SR-318
SR-318 is a potent and selective p38 MAPK inhibitor, with IC50 values of 5 nM and 32 nM for p38α and p38β, respectively. It effectively suppresses TNF-α release in whole blood (IC50 = 283 nM), making it a valuable tool for investigating inflammatory pathways in cellular and animal models of disease.
Product Specifications
CAS Number
2413286-32-3
Product Name Alternative
SR 318, SR318, SR-318, TNF-α, TNFR, TNF Receptor, whole, p38 MAPK, p38MAPK, p38α, p38α/β, p38β, Tumor Necrosis Factor Receptor, anti-inflammatory, anti-cancer, blood, Inhibitor, inhibit
Field of Research
Cell Biology, Signal Transduction
Purity
99.53% (May vary between batches)
Solubility
DMSO:125 mg/mL (271.99 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.7 mM)
Smiles
Nc1c (cnn1-c1ccccc1) C (=O) NCc1ccc (cc1) C (=O) NCCCC1CCCCC1
Molecular Formula
C27H33N5O2
Molecular Weight
459.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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