VTP50469
VTP50469 is a potent, orally bioavailable small molecule that selectively inhibits the Menin-MLL interaction with sub-nanomolar affinity (Ki = 104 pM) . It demonstrates robust anti-leukemic efficacy in both cellular assays and in vivo models, making it a valuable chemical probe for researching MLL-rearranged and NPM1-mutant leukemias.
Product Specifications
CAS Number
2169916-18-9
Product Name Alternative
Inhibit, Epigenetic Reader Domain, EpigeneticReaderDomain, Menin-MLL, Menin-MLL interaction, leukemia, Histone Methyltransferase, HistoneMethyltransferase, Inhibitor, differentiation, antiproliferative, Apoptosis, survival, protein-protein, VTP 50469, VTP50469, VTP-50469
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
98.31% (May vary between batches)
Solubility
DMSO:125 mg/mL (198.15 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.34 mM)
Smiles
CC (C) N (C (C) C) C (=O) c1cc (F) ccc1Oc1cncnc1N1CC2 (C1) CCN (C[C@H]1CC[C@@H] (CC1) NS (C) (=O) =O) CC2
Molecular Formula
C32H47FN6O4S
Molecular Weight
630.82
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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