Topiramate (Standard)

Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

Product Specifications

CAS Number

[97240-79-4]

Product Name Alternative

McN 4853 (Standard) ; RWJ 17021 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Carbonic Anhydrase; GABA Receptor; iGluR; Potassium Channel; Reference Standards; Sodium Channel

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/topiramate-standard.html

Purity

99.76

Smiles

NS(OC[C@]1(OC(C)(C)O2)[C@@H]2[C@H](OC(C)(C)O3)[C@H]3CO1)(=O)=O

Molecular Formula

C12H21NO8S

Molecular Weight

339.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67 (15) :2231-56.|[2]Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115 (1) :53-7.|[3]Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46 (8) :1097-104.