3-Oxo-5β-cholanoic acid
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid-derived metabolite that acts as a direct RORγt antagonist with a Kd of 1.13 μM, thereby suppressing TH17 cell differentiation. This mechanism supports its application in researching autoimmune and inflammatory diseases in both cellular and animal models.
Product Specifications
CAS Number
1553-56-6
Product Name Alternative
Cell, Dehydrolithocholic acid, DHLCA, differentiation, acid, 3 Oxo 5β cholanoic acid, 3-Oxo-5b-cholanoic acid, 3-Oxo-5beta-cholanoic acid, 3Oxo5βcholanoic acid, 3-Oxo-5β-cholanoic acid, 3-oxoLCA, bile, factor, Inhibitor, immune, inhibit, RAR-related orphan receptor, responses, RORγt, ROR, TH17, transcription
Field of Research
Metabolism Research
Purity
≥98% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM) ; DMSO:65 mg/mL (173.54 mM)
Smiles
C[C@H] (CCC (O) =O) [C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC (=O) CC[C@]4 (C) [C@H]3CC[C@]12C
Molecular Formula
C24H38O3
Molecular Weight
374.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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