CDDO-dhTFEA
CDDO-dhTFEA is a synthetic oleanane triterpenoid that dually activates the Nrf2 antioxidant pathway and inhibits the NF-κB inflammatory pathway. It has demonstrated efficacy in preclinical CKD models, reducing fibrosis, inflammation, and improving hemodynamics, supporting its research use in oxidative stress and fibrotic diseases.
Product Specifications
CAS Number
1191265-33-4
Product Name Alternative
Inhibitor, Nrf2, Keap1-Nrf2, inhibit, NF-κB, NF-kB, NFkB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, CDDOdhTFEA, CDDO-dhTFEA, CDDO dhTFEA, RTA dh 404, RTA dh404, RTA dh-404
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Purity
95.61% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.74 mM) ; DMSO:100 mg/mL (174 mM)
Smiles
[H][C@@]12CC (C) (C) CC[C@@]1 (CC[C@]1 (C) [C@]2 ([H]) C (=O) C[C@@]2 ([H]) [C@@]1 (C) CC[C@@]1 ([H]) C (C) (C) C (=O) C (=C[C@]21C) C#N) C (=O) NCC (F) (F) F
Molecular Formula
C33H45F3N2O3
Molecular Weight
574.72
Storage Conditions
-20°C
Notes
For research use only.
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