CDDO-dhTFEA

CDDO-dhTFEA is a synthetic oleanane triterpenoid that dually activates the Nrf2 antioxidant pathway and inhibits the NF-κB inflammatory pathway. It has demonstrated efficacy in preclinical CKD models, reducing fibrosis, inflammation, and improving hemodynamics, supporting its research use in oxidative stress and fibrotic diseases.

Product Specifications

CAS Number

1191265-33-4

Product Name Alternative

Inhibitor, Nrf2, Keap1-Nrf2, inhibit, NF-κB, NF-kB, NFkB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, CDDOdhTFEA, CDDO-dhTFEA, CDDO dhTFEA, RTA dh 404, RTA dh404, RTA dh-404

Field of Research

Cell Biology, Immunology & Inflammation, Signal Transduction

Purity

95.61% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.74 mM) ; DMSO:100 mg/mL (174 mM)

Smiles

[H][C@@]12CC (C) (C) CC[C@@]1 (CC[C@]1 (C) [C@]2 ([H]) C (=O) C[C@@]2 ([H]) [C@@]1 (C) CC[C@@]1 ([H]) C (C) (C) C (=O) C (=C[C@]21C) C#N) C (=O) NCC (F) (F) F