(S, R, S) -AHPC-Me hydrochloride
(S, R, S) -AHPC-Me hydrochloride, also known as VHL ligand 2 hydrochloride, is a key component for constructing PROTAC degraders like ARV-771. This potent VHL-recruiting ligand enables the targeted degradation of BET proteins, demonstrating high potency (DC50 <1 nM) in cellular models, including castration-resistant contexts.
Product Specifications
CAS Number
1948273-03-7
Product Name Alternative
E3 ligase-recruiting Moiety, E3 ligase Ligand 1, (S, R, S) AHPC Me hydrochloride, (S, R, S) AHPCMe hydrochloride, AHPC-Me Hydrochloride, inhibit, Ligand for E3 Ligase, Ligands for E3 Ligase, LigandforE3Ligase, Inhibitor, VHL, VHL ligand2, VHL ligand-2, VHL ligand 2, VHL ligand 2 Hydrochloride, VHL ligand 2 hydrochloride
Field of Research
Pharmacology & Drug Discovery
Purity
99.18% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM) ; DMSO:62 mg/mL (128.88 mM)
Smiles
Cl.C[C@H] (NC (=O) [C@@H]1C[C@@H] (O) CN1C (=O) [C@@H] (N) C (C) (C) C) c1ccc (cc1) -c1scnc1C
Molecular Formula
C23H33ClN4O3S
Molecular Weight
481.05
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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