Shield-1
Shield-1 is a cell-permeable, high-affinity ligand for FKBP12 that stabilizes mutant FKBP fusion proteins, enabling their conditional expression. This small molecule is utilized in both in vitro and in vivo studies for controlling protein stability within chemical biology and targeted protein degradation research.
Product Specifications
CAS Number
914805-33-7
Product Name Alternative
Destabilization domain, inhibit, NIH3T3, HEK293, Inhibitor, high-affinity ligand, FK506-binding protein, FKBP, Shld 1, Shld1, Shld-1, Shield 1, Shield1, Shield-1
Field of Research
Cell Biology, Immunology & Inflammation
Purity
98.05% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.68 mM) ; DMSO:250 mg/mL (333.82 mM)
Smiles
CC[C@H] (C (=O) N1CCCC[C@H]1C (=O) O[C@H] (CCc1ccc (OC) c (OC) c1) c1cccc (OCCN2CCOCC2) c1) c1cc (OC) c (OC) c (OC) c1
Molecular Formula
C42H56N2O10
Molecular Weight
748.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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