UC-514321
UC-514321 is a small molecule STAT3/5 inhibitor that downregulates TET1 expression. It demonstrates efficacy against acute myeloid leukemia (AML) in both cellular and animal models, showing promising therapeutic potential with a favorable toxicity profile. This compound is a valuable research tool for investigating oncogenic signaling and epigenetic regulation in hematological malignancies.
Product Specifications
CAS Number
299420-83-0
Product Name Alternative
Apoptosis, AML, acute, leukemia, Inhibitor, inhibit, myeloid, low, STAT3, STAT, toxicity, UC 514321, UC514321, UC-514321
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.00% (May vary between batches)
Solubility
H2O:50 mg/mL (113.23 mM) ; DMSO:25 mg/mL (56.62 mM)
Smiles
CC (C) (C) c1cc (cc (c1O) C (C) (C) C) C (N1CCOCC1) c1cc2OCOc2cc1O
Molecular Formula
C26H35NO5
Molecular Weight
441.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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