1-Naphthohydroxamic acid
1-Naphthohydroxamic acid is a selective HDAC8 inhibitor (IC50 = 14 μM) with minimal activity against HDAC1 and HDAC6 (IC50 >100 μM) . It induces tubulin acetylation without affecting global histone H4 acetylation or total intracellular HDAC activity, making it a useful tool for studying HDAC8-specific roles in cellular processes.
Product Specifications
CAS Number
6953-61-3
Product Name Alternative
Deacetylate, hyperacetylated, Histone deacetylases, HDAC6, HDAC, HDAC1, HDAC8, Inhibitor, inhibit, clone, 1Naphthohydroxamic acid, 1-Naphthohydroxamic acid, 1 Naphthohydroxamic acid, acetylation, anti-proliferation, tubulin
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
99.19% (May vary between batches)
Solubility
DMSO:125 mg/mL (667.77 mM)
Smiles
ONC (=O) c1cccc2ccccc12
Molecular Formula
C11H9NO2
Molecular Weight
187.19
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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