A-385358
A-385358 is a potent and selective small molecule inhibitor of Bcl-xL, exhibiting a Ki of 0.80 nM, with 84-fold selectivity over Bcl-2. This compound is a valuable research tool for studying apoptosis mechanisms and has been utilized in both in vitro and in vivo models to investigate cancer biology and therapeutic resistance.
Product Specifications
CAS Number
406228-55-5
Product Name Alternative
Inhibit, Inhibitor, Bcl-2 Family, Bcl-2, Bcl-xL, A385358, A-385358, A 385358
Field of Research
Cell Biology
Purity
97.40% (May vary between batches)
Solubility
DMSO:45 mg/mL (70.33 mM) ;10% DMSO+90% Saline:2 mg/mL (3.13 mM)
Smiles
CN (C) CC[C@H] (CSc1ccccc1) Nc1ccc (cc1[N+] ([O-]) =O) S (=O) (=O) NC (=O) c1ccc (cc1) N1CCC (C) (C) CC1
Molecular Formula
C32H41N5O5S2
Molecular Weight
639.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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